Results of Curative Treatment of Prostate Cancer by External Radiotherapy in Lome

Introduction: External radiation therapy is one of the treatment options for localized prostate cancer. The aim of our study was to evaluate the results of this treatment in the curative management of prostate cancer patients in Togo.

Materials And Methods: This was a retrospective descriptive study of patients followed up in Togo who were treated with curative external radiotherapy for prostate cancer at the International Cancer Center in Lomé from 2021 to 2023. The parameters studied included age, initial total PSA, histological type, Gleason score, D’Amico staging, radiation characteristics, associated treatments, PSA progression, and side effects.

Results: A total of 61 cases were collected, representing a frequency of 20 cases per year. The average age of patients was 69.2 ± 2 years. Patients at high risk of AMICO accounted for 85.3% of cases. The initial PSA was 48.9 ± 9.3 ng/ml. All patients underwent prostate irradiation using the VMAT technique. Hormone therapy was combined with external radiotherapy in 95.1% of cases. Side effects were observed in 63.9% of patients during treatment, with a predominance of urinary disorders (44.3%) followed by digestive disorders (14.7%), with significant regression in the first few months. Biological recurrence was recorded in 6.5% of cases. Overall survival and recurrence-free survival at 1 year was 98.4%.

Conclusion: External radiation therapy, whether combined with hormone therapy or not, is one of the main curative options for prostate cancer. Individual screening and early consultation are essential to promote early diagnosis and, consequently, effective curative treatment.

Keywords: External Radiation Therapy, Curative Treatment, Prostate Cancer, Togo.